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The Vaughan family was an enterprising family who were prominent in Lagos and Abeokuta during the second half of the nineteenth and early twentieth century. The head of the family was the late J.C. Vaughan, an African American Baptist missionary from South Carolina. He was a supporter of Baptist causes in Nigeria and helped finance the first independent African Church: the Native Baptist Church, which was later called Ebenezer Baptist Church. The Church then had notable pastors such as Ladejo Stone, L. Tubi and Mojola Agbebi. Vaughan also founded an hardware business in 1873. After his death, the store was managed by his sons, J.W. Vaughan and B.C. Vaughan.

Another notable member of the family was J.C. Vaughan, who was a founding member of the Lagos Youth Movement and was a medical doctor in Lagos.